心力衰竭患者血清心肌肌钙蛋白与心功能的相关性研究

Correlation of Serun Cardiac Troponin with Cardiac Function in the Patients with Congestive Heart-failure

目的:观察充血性心力衰竭(CHF)患者血清心肌肌钙蛋白I(CTn-I)水平及其与心功能的相关性。方法:选择160例CHF患者,应用微粒子化学发光法测定血清CTn-I水平。采用NYHA心功能分级法及左室射血分数(LVEF)值进行分类,并进行组间均数t检验及相关性分析。结果:心功能(NYHA)为Ⅰ、Ⅱ、Ⅲ、Ⅳ级者,其血清CTn-I水平分别为(0.04±0.01)μg/L,(0.09±0.02)μg/L,(0.20±0.11)μg/L,(0.35±0.21)μg/L。160例患者中LVEF≤35%者,CTn-I水平为(0.24±0.15)μg/L;LVEF>35%者CTn-I为(0.08±0.03)μg/L。LVEF值与CTn-I呈负相关(r=-0.590,P<0.01)。结论:CHF患者血清CTn-I水平升高,其升高程度与心力衰竭严重程度相平行。

Objective： To investigate the level of serum cardiac troponin Ⅰ （CTn-Ⅰ） and it＇s correlation with cardiac function in the patients with congestive heart-failure. Methods： The levels of serum cardiac troponin Ⅰ （CTn-Ⅰ） of 160 patients with congestive heart-failure were detected using microsome chemiluminescence method. According to the grade of cardiac function （NYHA） and left ventricular ejection fraction （LVEF）,the patients were divided into different groups, and the average figure and the correlative analysis were examined by statistical method. Results： The grade of cardiac function was Ⅰ , Ⅱ , Ⅲ and Ⅳ respectively, their levels of serum cardiac troponin Ⅰ （CTn-Ⅰ） were （0.04±0.01）μg/L, （0. 09±0. 02）μg/L,（0.20±0.11）μg/L and （0.35±0.21）μg/L respectively. The level of serum cardiac troponin Ⅰ（CTn-Ⅰ） was 0. 24±0.15μg/L in the group of left ventricular ejection fraction （LVEF） ≤35%, while those in the group of left ventricular ejection fraction （LVEF）〉35% was 0. 08±0.03μg/L. The left ventricular ejection fraction （LVEF） was negatively correlated with serum cardiac troponin Ⅰ（CTn-Ⅰ）. Conclusion： The levels of serum cardiac troponin Ⅰ（CTn-Ⅰ） of the patients with congestive heart-failure increased clearly and the increased degree and the severe degree of heart failure were of equal rank.