甲亢患者的血流动力学研究

Investigation on kinetics Of Bloodstream in the Patients with Hyperthyroidish

目的:应用TCD探讨甲亢患者的血流动力学变化及临床价值。方法:按常规检测50例青年甲亢患者颅内各动脉的血流动力学指标,与30例健康正常组对照,50例患者并分为血流速度显著增高(A组)、中度增高(B组)、轻度增高(C组)三组。结果:所有患者血流速度均增高、收缩峰高尖,搏动指数正常,高代谢征候群者占70%,伴突眼者占60%。A组T3、T4值显著高于B、C组,TSH值显著低于B、C组,B组T3、T4值显著高于C组,TSH值显著低于C组。A组其症状明显者比例明显高于其它两组。结论:脑血流速度的增高程度可初步反映甲亢的严重程度,并与症状发生程度有相关性,TCD可用来评价甲亢的严重程度,并与症状发生程度有相关性,TCD可用来评价甲亢的严重程度并可提高早期确诊率。

Objective： To investigate the homodynamic changes and its clinical significance in the patients with hyperthyroidism by TCD. Methods： Fifty patients with hyperthyroidism and 30 health persons were examined for intracranial homodynamic indexes by TCD. Fifty patients were divided into 3 groups based upon their increased velocities ： the highest v velocity group（group A）, the moderate velocity group （group B） and the mid velocity group（group C ）. Results： Increased velicities were found in all patient groups. The systolic velocily was high and sharp , but the pulsatility index was normal. A high-metabolism was found in 70 ~ patients and exophthalmia was in 60% patients. T3 and T4 of group A were significantly higher than those of group B and.C, while TSH of group A was significantly lower than those of group B and C;T3 and T4 of group B were significantly higher than group C, while TSH of group B was significantly lower than those of grou C. Symptom were most often found in group A than those in the other 2 groups. Conclusion： The severances of hyperthyroidism can be observed by the increased cerenbral blood velocities which would affect symptom. TCD can help us in judging the severity of hyperthyroidism and effectiveness of therapy, it may be possible to raise the early diagnostic rate also.