VEGF、P53、P16的表达与胶质瘤恶性程度的关系

The Relevance of VEGF、P53 and P16 with Glioma Malignant Degree

目的研究VEGF、P53、P16在胶质瘤中的表达,探讨其与肿瘤恶性程度的关系。方法用免疫组化S-P法检测VEGF、P53、P16在胶质瘤中的表达。结果胶质瘤中VEGF、P53、P16的表达在低级别组与高级别组之间存在显著差异,是影响患者预后的主要因素。结论VEGF、P53、P16在胶质瘤中的表达与其恶性程度相关。

Objective To examine the expression of VEGF, P53 and P16 in glioma, and to investigate the relevance of VEGF, P53 and P16 with tumor malignant degree. Methods To detect the expression of VEGF, P53, and P16 in tumor tissues with S-P method of immunohistochemistry.Resuits The expression of VEGF, P53, and PI6 was significantly different between low grade ang hige grade glioma. Conclusions The expression of VEGF, P53, and P16 was correlated with glioma malignant degree.