湖沼地区日本血吸虫病家庭聚集性的研究

FAMILIAL AGGREGATION OF PATIENTS INFECTED WITH SCHISTOSOMA JAPONICUM IN MARSHLAND AREA

目的通过对实验区感染病例家庭分布情况以及感染者亲属的感染情况的分析,探讨日本血吸虫病家庭聚集性以及家庭在血吸虫病传播中的作用。方法选择江西省九江市都昌县塘美行政村作为实验点,2002年对全村的1064人进行了病原学检查,并对其中的1015人进行了问卷调查和家庭人员调查。2003年对其中的两个高感染村418人进行追踪随访,12月份进行回顾性疫水接触调查。调查资料用ACCESS2002建立数据库,用SPSS做统计分析。结果江西塘美村血吸虫感染病例呈现家庭聚集性现象,感染者的亲属更易感染血吸虫病,血缘关系越近,发病机会越大。结论湖沼地区日本血吸虫病存在家庭聚集性,日本血吸虫感染不能排除受遗传因素影响。

Objective To explore the distribution of patients infected with Schistosorna japonicurn in the household, in order to determine the importance of common environmental effects in the transmission of S. japonicurn. This would enable the identification of possible genetic effects controlling infection through distribution analysis using both pedigrees and households. Methods The study population was consisted of 1 064 individuals from Tangmei Village in Jiangxi Province, China. In 2002, they were examined using the standard Kato-Katz thick smear technique to assess infection status. Of these, 1 015 completed a baseline questionnaire in 2002, 418 individuals were followed up in 2003. Pedigree data was obtained both in 2002 and 2003 and retrospective water contact was surveyed in December 2003 at the end of the study period. Results 1） Familial aggregation of infection showed to be non-random; 2） Relatives of infected individuals showed an increased infection risk and the closer the relationship between individuals, the further the increase in risk. Conclusion Familial aggregation is non-random and could be a result of genetic effects as well as other environmental components. Further investigation is required to establish the nature of these effects and their roles in transmission.