育龄妇女弓形虫感染的血清学调查

A SEROLOGICAL INVERSTIGATION ON TOXOPLASMA INFECTION IN FERTILE WOMAN

目的探讨弓形虫感染对育龄妇女生殖健康的影响。方法采用金标免疫诊断试验和酶联免疫吸附试验测定4310例育龄妇女血清弓形虫抗体IgG、IgM和循环抗原。结果4310例育龄妇女中血清弓形虫抗体或循环抗原阳性606例,阳性率14.06%,阳性组中流产、死胎、畸形发生率高于阴性组(P<0.01),妇科疾病如子宫肌瘤、宫外孕、盆腔炎、不孕症的患病率也显著高于阴性组(P<0.01)。结论育龄妇女弓形虫感染与异常妊娠结局及某些妇科疾病密切相关,加强对育龄妇女弓形虫血清学监测和健康教育具有十分重要的意义。

Objective To explore the impact of toxoplasma infection on fertile woman＇s health . Methods The dot immunogold filtration （DIGFA） and ELISA were used to detect the IgG, IgM of toxoplasmosis antibody and circulation antigen（CAg） in sera from 4 310 fertile women. Results The total positive rate of IgG, IgM and CAg was 14.06%（606/4310）. The abortion rate, fetal stillborn foetus rate and monster rate in positive group were higher than that of negative group（P〈0. 01）. The morbidity of myoma of uterus, ectopic pregnancy, pelvic inflammation and infertility in positive group was significantly higher than that in negative group （P〈0. 01） Conclusion The abnormal pregnancy, some gynecopathy are closely related with toxoplasma infection in fertile women. It suggested that it is very important that toxoplasmosis serological surveillance and health education are conducted among fertile women.