PPARγ激活剂罗格列酮对兔动脉粥样硬化斑块消退的影响

Effect of PPARγ agonist rosiglitazone on regression of the atherosclerotic plaques in rabbits

Aim To explore the prevention of atherosclerosis by PPARγ agonist rosiglitazone. Methods 24 male New Zealand white rabbits weighing 1.8 to 2.2 kg were randomly divided into 3 groups: control group, normal rabbit chow; cholesterol group,1% cholesterol diet; rosiglitazone group, 1% cholesterol diet supplemented with rosiglitazone 0.5 mg·kg-1·d-1 for 6 weeks. Rabbits in cholesterol group and rosiglitazone group were sequentially fed 1% cholesterol-containing diet for 16 weeks. At the end of the experiment, blood glucose, serum lipids levels, ratio of plaque area to aorta area and ratio of intima to media were determined. Results Hypercholesterolemia was successfully reproduced in rabbits. Adnimistration of rosiglitazone significantly decreased serum TC and LDL-C. The ratio of intima to media and ratio of plaque area to aorta area were also reduced. Conclusion Rosiglitazone could prevent atherosclerosis by decreasing levels of TC and LDL-C.

Aim To explore the prevention of atherosclerosis by PPART agonist rosiglitazone. Methods 24 male New Zealand white rabbits weighing 1.8 to 2.2 kg were randomly divided into 3 groups： control group, normal rabbit chow; cholesterol group, 1% cholesterol diet; rosiglitazone group, 1% cholesterol diet supplemented with rosiglitazone 0.5 mg·kg^-1·d^-1 for 6 weeks. Rabbits in cholesterol group and rosiglitazone group were sequentially fed 1% cholesterol-containing diet for 16 weeks. At the end of the experiment, blood glucose, serum lipids levels, ratio of plaque area to aorta area and ratio of intima to media were determined. Results Hypercholesterolemia was successfully reproduced in rabbits. Adnimistration of rosiglitazone significantly decreased serum TC and LDL-C. The ratio of intima to media and ratio of plaque area to aorta area were also reduced. Conclusion Rosiglitazone could prevent atherosclerosis by decreasing levels of TC and LDL-C.