伽玛刀对受压迫猫视神经电生理学的影响

Electrophysiological influences of gamma knife at different doses on the compressed cat optic nerve

目的探讨引起受压迫的猫视神经电生理学变化的最小伽玛刀剂量。方法制作20只猫视神经压迫动物模型,模型制成后2个月,随机分为5组,每组4只,1组作为对照,其余4组分别接受10、11、12、13 Gy伽玛刀的照射,照射后分别于3 d、1周、半个月、1、2、3、4、5个月进行电生理监测。结果10 Gy组在伽玛刀照射后1周内有电生理的变化,这种变化在半个月时有所恢复,随着时间的延长逐渐恢复。11 Gy以上组在伽玛刀照射后出现了不可逆电生理学的异常变化,这种变化随着时间的延长而加重。结论10 Gy可引起受压迫的猫视神经电生理学的可逆性变化,11 Gy可引起视神经不可逆的放射性损伤。

Objective To investigate the electrophysiological influences of gamma knife at different doses on the compressed cat optic nerve. Methods Model of compressed optic nerve was established in 20 cats. Two months later, the 20 cats were randomly divided into 5 equal groups. Four groups accepted the irradiation of gamma knife at the dose of 10, 11, 12, and 13 Gy respectively. One group was used as controls. Pattern visual evoked potential examination was used 3 days, 1 week, half a month, and 1, 2, 3, 4, and 5 months after the beginning of irradiation. Results Electrophysiological changes could be observed 1 week later began to recover half a month later and then gradually recovered to normal with the lapse of time. Irreversible electrophysiological changes were observed in the groups undergoing gamma knife at the doses of 11 Gy and over, and these changes aggravated with the lapse of time. Conclusion 10 Gy is the minimum dose of gamma knife that cause beneficial electrophysiological changes in the compressed cat optic nerves. The minimum dose that causes irreversible damage is 11 Gy.