普鲁卡因阻滞对神经断伤所致神经元超微结构破坏的保护作用实验研究

ProtectiveActionofProcaineonUltrastucturesofα┐MotoneuronsfrombeingDestroyedbyNerveTran┐section:anExperimentalStudy

为了明确普鲁卡因阻滞对神经断伤所致脊髓运动神经元超微结构破坏的保护作用，选用Ｓｐｒａｇｕｅ－Ｄａｗｌｅｙ大鼠，设计臂丛神经根性损伤的实验模型，研究了神经断伤后脊髓运动神经元超微结构的改变及普鲁卡因阻滞的影响．实验结果：（１）神经断伤后脊髓运动神经元的线粒体，尼氏体和溶酶体明显破坏．（２）单位面积胞浆中尼氏体和溶酶体面积明显缩小．（３）神经断伤后脊髓运动神经元超微结构的破坏可以用２％普鲁卡因阻滞加以阻断．结果显示：神经断伤前用２％普鲁卡因阻滞，对脊髓运动神经元的超微结构有明显的保护作用．

Inordertomakeitsurethat2%procaineblockingcouldprotectultrastucturesofα-mo-toneuronsinspinalcorddestroyedbynervetransection,Sprague-Dawleyratswereusedastheanimalmodelsofbrachialplexusrootsinjuries.Ultrastucturalchangesofα-motoneuronsinspinalcordwerestudied.Results:(1)Thenumbersofmitochondria,Nisslbodyandlysosomsdecreased.(2)Nisslbodyareaandlysosomalareawerereduced.(3)TheUltrastructuralchangesofα-motoneuronscouldbecheckedbyblockingbrachialplexusrootswith2%procaine.Theauthorsconcludedtheblockingnervewith2%procainecouldprotecttheultrastructuresofα-motoneuronsinspinalcordfrombeingde-stroyedbynervesection.