慢性疲劳综合征患者心理学特征的研究

Cognitive function and psychological characteristics of patients with chronic fatigue syndrome

目的研究我国慢性疲劳综合征(CFS)患者的认知功能和心理学特征。方法通过表格病例记录临床症状及使用《临床记忆量表手册》、SCL-90、Hamilton抑郁量表(HAMD)和Hamilton焦虑量表(HAMA)对91例CFS患者和30名健康对照进行记忆力评定和心理学测试,结合临床表现,分析CFS患者的认知功能、心理学异常的特点。结果CFS组记忆商为85±14,对照组为98±12,两者比较t=4·627,P=0·000。CFS患者临床计算力、工作效率下降,其SCL-90测试总分为192±47,对照组为140±46,两组比较t=5·297,P=0·000;CFS患者HAMD为9·9±6·1,对照组为6·5±2·5,两组比较t=2·948,P=0·004;CFS患者HAMA分值为9·9±7·0,对照组为5·9±2·9,两组比较t=3·015,P=0·003。结论我国CFS患者认知功能受损明显,广泛存在心理学异常,其特点与原发心理疾病不同。

Objective To investigate the cognitive function and psychological characteristics of the patients with chronic fatigue syndrome （CFS） in China and analyze its relation with primary psychological diseases. Methods Ninety-one patients with CFS who visited the People＇s Hospital, Peking University,in Beijing from Beijing, Shanghai, Tianjin, Heilongjiang, Jilin, Hebei, Inner Mongolia, Shanxi, Shandong, Sichuan, Gansu, Fujian, and Guangdong, 42 males and 49 females, aged 37 ± 7, 43% of which had the record of formal schooling of regular college course or over and 21 of which had the record of formal schooling of college for professional training, and 58% of which showed clear causes, diagnosed by the CDC criteria 1994, underwent case history collection, physical examination, necessary laboratory test, memory test, and SCL-90, Hamilton depression rating scale （HAMD） , and Hamilton anxiety rating scale （HAMA） testing. Thirty healthy persons, 14 males and 16 females, aged 37±7, were used as controls. , A table of case file was established based on the CDC criteria 1994 for each patient to record the relevant data. Independent-Samples T Test was used to compare the memory quotient, the total score and general mean score of SCL-90, the score of HAMD and HAMA. Analyzed the impairment of cognitive function and psychological characteristics of patients with CFS. Results The most common symptoms was descent of remembrance and /or attention （82/91,90% ）. The memory quotient of the CFS patients was 85 ± 14, significantly lower than that of the healthy controls（98 ± 12, t = 4.627, P = 0. 000）. The total score of SCL-90 of the CFS patients was 192 ±47, significantly higher than that of the healthy controls（ 140±46, t =5. 297, P =0.000）. The symptoms with a factor score ≥2.0 in SCL-90 included obsessive-compulsive symptoms （61/91, 67% ）, somatization （61/91,67 % ） , depression （57/91,63%） , and anxiety （49/91,54%）. The HAMD score of the CFS patients was 9. 9±6. 1, significantly higher than that of the healthy controls （6.5 ± 2.5, t = 2. 948, P = 0.004）. The HAMA score of the CFS patients was 9.9 ＋ 7. 0, significantly higher than that of the healthy controls （5.9 ±2.9, t = 3. 015, P = 0. 003 ）. Conclusion The CFS patients in China have an obvious impairment of remembrance and show different psychological abnormalities that are different from those of the patients with primary psychological diseases.