宫颈鳞癌组织中核因子-κBp65和p53蛋白的表达

Expression of NF-κBp65,p53 protein in tissues of cervical squamous carcinoma

目的 探讨NF κBp65和p53蛋白在宫颈鳞癌、宫颈上皮内瘤样病变(CIN)组织和正常宫颈组织中的表达及其意义。 方法 采用免疫组织化学技术(S P法),分别检测38例宫颈鳞癌组织、21例CIN组织和12例正常宫颈组织中NF κBp65和p53蛋白的表达。 结果 NF κBp65和p53蛋白在宫颈鳞癌中的阳性表达率均明显高于CIN组织和正常宫颈组织,差异均有显著性(P<0.01,P<0. 05)。 结论 NF κBp65和p53蛋白在宫颈鳞癌的发病过程中起着重要的作用。

Objective To explore the expressions of NF-κBp65 and p53 protein in tissues of cervical squamous carcinoma, cervical intraepithelial neoplasia （CIN）, normal cervical tissues and their significance. Methods The expressions of NF-κBp65 and p53 protein in 38 cases of cervical squamous carcinoma tissues, 21 cases of cervical intracpithelial neoplasia and 12 cases of normal cervical tissues were examined by SP Immunohistochemistry method. Results The positive expression rates of NF-κBp65 and p53 protein in cervical carcinomas tissues were significantly higher than those in CIN tissues and normal cervical tissues （ P 〈 0.01 ,P 〈 0.05）. Conclusion NF-κBp65 and p53 play important role in the development of cervical squamous carcinoma.