他汀类药物与痴呆

Statins and Dementia

他汀类药物已在临床广泛使用,除降血脂作用外,其对痴呆的防治作用正逐渐引起人们的关注。在中年人中高胆固醇血症可能与痴呆呈正相关,而在老年人中则呈负相关。他汀类药物可能通过调节脑内胆固醇代谢、抑制载脂蛋白E表达、减少β淀粉样蛋白形成、降低卒中风险和增强胆碱能神经元功能等机制起到防治痴呆的作用。

Statins have been widely used clinically, apart from lowing serum cholesterol, their effect of prevention and treatment of dementia is arousing general concern. Hypercholesterolemia in middle-aged adults may have positive correlation with dementia, while in the elderly may have negative correlation with dementia. Statins may prevent dementia through several mechanisms, such as regulation of cholesterol metabolism, inhibition of apolipoprotein E expression, inhibition of β-amyloid formation, reduction of stroke risk, and enhancement of cholinergic neuronal function.