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死亡相关蛋白激酶与肿瘤 被引量：2

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摘要 死亡相关蛋白激酶(DAPK)是钙离子/钙调素调节的丝氨酸/苏氨酸激酶。DAPK有一个多区结构,具有潜在的转录活性,色氨酸308自身磷酸化被认为是其基本状态的一个自控装置。DAPK参与干扰素-γ、TNF-α、p53和TGF-β等介导的细胞凋亡,在整个凋亡系统中发挥着重要作用。DAPK被认为是抑癌基因,与肿瘤的发生、发展、转移密切联系,其启动子CpG岛甲基化是其在表观遗传学上调节的重要方式。DAPK在肿瘤早期诊断、评价预后及基因靶向治疗等方面有重要意义。
作者 闵卫利 王西京
机构地区 西安交通大学第二医院肿瘤外科
出处 《国外医学（外科学分册）》 2005年第6期446-449,共4页 Foreign Medical Sciences(section of Surgery)
关键词 死亡相关蛋白激酶 凋亡 肿瘤
分类号 R730.2 [医药卫生—肿瘤]
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参考文献19

  • 1Preuss U, Bierbaum H, Buchenau P, et al. DAP-like kinase, a member of the death-associated protein kinase family, associates with centrosomes, centromers, and the contractile ring during mitosis. Eur J Cell Biol, 2003,82(9): 447-459.
  • 2Raveh T, Berissi H, Eisenstein M, et al. A functional genetic screen identifies regions at the C-terminal tail and death-domain of death-associated protein kinase that are critical for its proapoptotic activity. Proc Natl Acad Sci USA, 2000, 97: 1572-1577.
  • 3Velentza AV, Schumacher AM, Weiss C, et al. A protein kinase associated with apoptosis and tumor suppression. J Biol Chem,2001,276(42): 38956-38965.
  • 4Bialik S,Bresnick AR,Kimchi A, et al. DAP-kinase-mediated morphologicalchanges are localization dependent and involve myosin-Ⅱphosphorylation. Cell Death Different, 2004, 11(6): 631-644.
  • 5Won WJ ,Kuo JC, Yao CC, et al. DAK-kinase induces apoptosis by suppressing intergrin activity and disrupting matrix survival signals.J Cell Biol, 2002,159(1): 169-179.
  • 6Cohen O, Inbal B, Kissil Jl, et al. DAP-kinase participates in TNF-alpha and Fas-inducedapoptosis and its function requires the death domain. J Cell Biol,1999,146: 141-148.
  • 7J ang CW, Chen CH, Chen CC, et al. TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase. Nat Cell Biol,2001, 10: 10.
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同被引文献12

  • 1党艳丽,马晓旗,毕红梅,郑维国,辛晓燕.5-氮胞苷对宫颈癌细胞系DAPK1异常甲基化的影响[J].西安交通大学学报（医学版）,2005,26(1):48-51. 被引量：8
  • 2Cohen O, Feinstein E, Kimchi A. DAP-kinase is a Ca^2+/calmodul independent, cytoskeletal-associated protein kinase, with cell death inducing functions that depend on its catalytic activity [J]. EMBO J, 1997, 16(5):998-1008.
  • 3Narayan G,Arias-Pulido H, Kou IS, et al. Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri:its relationship to clinical outcome[J]. Mol Cancer, 2003, 13(2): 24-26.
  • 4Bialik S, Kimch A. DAP-kinase as a target for drug design in cancer and diseases associated with accelerated cell death [J]. Semin Cancer Biol, 2004,14(4): 283-294.
  • 5Uehara E, Taheuchi S, Tasaka T, et al. Aberrant methylation in promoter associated CpG is islands of multiple genes in therapy-related leukemia[J]. Int J Oncol, 2003, 23 (3): 693-696.
  • 6Cohen O, Feinstein E, Kimchi A. DAP-kinase is a Ca^2+/calmodulin- dependent, cytoskeletal-associated protein kinase, with cell deathinducing functions that depend on its catalytic activity. EMBO J, 1997:998-1008.
  • 7Bialik S, Kimchi A. DAP-kinase as a target for drug design in cancer and diseases associated with accelerated cell death. Semin Cancer Biol, 2004, 14:283-294.
  • 8Reddy AN, Jiang WW, Kim M, et al. Death-associated protein kinase promoter hypermethylation in normal human lymphocytes. Cancer Res, 2003, 63:7694-7698.
  • 9Narayan G, Arias-Pulido H, Koul S, et ah Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri : its relationship to clinical outcome, Mol Cancer, 2003, 2:24-26.
  • 10叶梅,夏冰,李冬青,周峰,郭秋莎,刘铭球.死亡相关蛋白激酶基因在胃癌组织中的表达[J].武汉大学学报（医学版）,2007,28(6):715-718. 被引量：3

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国外医学（外科学分册）
2005年 第6期

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