铜绿假单胞菌耐药特性的分析及其临床抗感染用药的方向性初探

The primary discussion to the drug resistance analysis of the Pseudomon aseruginosa and direction of the drugs in clinical antiinfection

目的分析导致临床感染的242株铜绿假单胞菌的来源分布及其耐药情况,为临床预防感染以及合理用药提供依据。方法采集来自各临床科室的送检标本,进行细菌学培养鉴定及药敏试验。结果铜绿假单胞菌以呼吸道和伤口创面感染为主要临床感染来源,抗感染药物中敏感率以特美汀(90.1%)、亚胺培南(87.2%)、特治星(85.1%)为最高,次为哌拉西林(84.7%)、妥布霉素(83.1%)和左氧沙星(82.6%);而耐药率最高的是头孢唑啉(99.6%)、头孢替坦(99.6%)、氨苄西林(97.5%),次为复方新诺明(90.9%)、头孢曲松(87.2%),其耐药情况较严重。结论铜绿假单胞菌在临床感染中占有非常重要的地位,其单一及多重耐药情况均较严重,需高度重视,且要加强预防措施,以降低其感染率。合理谨慎使用抗生素仍是延缓其耐药株快速升高的最好办法犤1犦。

Objective to analyze the .source and the drug resistance of 242 strains Pseudnmon aseruginosa which cause clinical infection, which offers basis for prevention of clinical infection and the reasonable use of drugs. Methods collect all kinds of the clinical specimens, which are used to culture, identify and sensitivity testing. Results the main clinical infection source of Pseudomnn aseruginosa is the infection of respiratory and cut. In all of the antibiotics, The most sensitive antibiotic is Ticarcillin/CA（90.1%）, Imipenem（87.2%）, Piperacilin/tazobactam（85.1%）, the next is Piperacillin（84.7%）, Tobramycin（83.1%）,and Levofloxacin（82.6%）; and the most resistant is Cefazolin（99.6%）, Cefotetan（99.6%）, Ampicilin（97.5%）, the next is Trimethoprin（90.9%）,Ceftriaxone（87.2%）, which is very serious. Conclusions Pseudomon aseruginosa is very important in clinical infection and its single and multiresistance of antibiotics is very serious. So it＇s necessary to pay more attention and strengthen preventive measures to reduce infection, using antibiotics reasonably and carefully is also the best way to delay the resistant stains appear quickly.