反式-对戊基环己基苄基甲酮的合成

Synthesis of trans-p-pentylcyclohexylbenzylketone

以反式-对戊基环己基甲酸为原料,经酰氯化,氨解,脱水,G rignard反应四步合成乙烷类液晶中间体反式-对戊基环己基苄基甲酮.对G rignard反应合成条件进行了研究,获得了优化反应条件是:采用四氢呋喃和甲苯混合溶剂,n(C6H5CH2MgC l)∶n(C5H11C6H10CN)=1∶1.5,反应10h,总收率为41.5%.目标产物经IR和1HNMR确证其结构.

Trans-p- Pentylcyclohexylbenzylketone is an intermediate to synthesize ethane＇s liquid crystal. Target molecule was prepared from trans - p - Pentylcyclohexanecarboxylic acid through acylchloridation,ammonolysis, dehydration and grignard reaction. Synthesis condition of grignard reaction was researched, and the optimum reaction conditions were as follows ： with tetrahydrofuran and methylbenzene as reaction solvents,n（C6H5CH2MgCl）： n（C5H11C6H10CN） = 1：1.5 ,and 10h treaction time,a total yield of 41.5% was achieved. The structure of the compound was characterized by IR, ^1HNMR.