新生儿败血症甲状腺功能检测研究

Study on the thyroid function in neonate with septicemia

目的探讨新生儿败血症时甲状腺功能的变化及意义。方法对56例新生儿败血症进行了游离三碘甲状腺氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素刺激激素(TSH)检测,其中21例恢复期进行了复查,并同时检测C反应蛋白(CRP)。结果新生儿败血症患儿血清FT3水平下降,低于对照组;病情越重,程度越低;FT3和CRP呈负相关;恢复期升至正常对照组水平。结论全身感染时新生儿存在甲状腺功能的变化,病情越重,变化越明显。

Objective To study the role of thyroid function in neonate with septicemia. Methods Free triiodothyronine （FT3 ）, free thyroxine （FT4 ） and thyrotropic-stimulating hormone （TSH） were determined in 56 cases of neonate with septicemia, C-reactive protein （CRP） in serum was also determined. 21 cases were reexamined in the convalescence phase. Results Compared with control group, the level of FT3 in serum was decreased in neonate septicemia. The sicker the patient was, the lower the level of FT3 was . There was no significant difference between the level of FT3 in the acute and convalescence phase. FT3 and CRP showed a significantly negative correlation. Conclusions The variation of thyroxine level existes in neonate septicemia. The sicker the patient is, the more significant change of FT3 level is.