高乌甲素贴片治疗肝癌疼痛的疗效

Observation on clinical effect of lappaconitine adhesive patch in treatment of the pain of liver cancer

目的观察高乌甲素贴片治疗肝癌中、重度疼痛的镇痛效果及不良反应。方法将103例中、重度疼痛肝癌患者随机分成两组,分别应用高乌甲素贴片和萘普待因片进行治疗,在用药后15 d评价其疗效及不良反应。结果疼痛缓解率高乌甲素贴片组为83.0%,萘普待因片组为78.0%,两组比较差异无显著性,两组对中度疼痛的镇痛效果均优于重度疼痛(P<0.05),但高乌甲素贴片组胃部不适、头晕及嗜睡等不良反应发生率更低(P<0.05)。结论高乌甲素贴片对肝癌疼痛尤其是中度疼痛镇痛效果好,使用方便,不良反应轻微。

Objective To observe the analgesic effect and side effects of lappaconitine adhesive patch in treatment of moderate to severe pain of liver cancer. Methods 103 live cancer patients with moderate or severe pain were assigned randomly to two groups： lappaconitine adhesive patch treatment group and naproxen codeine tablet treatment group. The analgesics effect and side effects were evaluated after 15 days. Results The pain-relief rate between two groups was similar, but in lappaconitine adhesive patch group, the side effects of digestive tract, giddiness and drowsiness were less than that in naproxen codeine group（ P〈0.05 ）. Conclusion Lappaconitine adhesive patch is an effective and convenient drug to treat the pain of liver cancer, especially to moderate pain, and has slight side effects.