阿奇霉素包合工艺研究

Study on Inclusive Technology of Azithromycin

目的:探讨饱和水溶液法制备阿奇霉素-β-环糊精包合物的最佳制备工艺。方法:采用正交设计方法优化制备工艺。结果:优选出的最佳制备工艺为阿奇霉素:β-环糊精(摩尔比)为1:1,包合温度为50℃,搅拌时间为2h。结论:按此工艺条件制备包合物,产品的含药量达18.87±0.25%。

Objective： To study the optimal of preparing azithromycin-β-cyclodextrin （AM-β -CD） inclusion complex by saturated aqueous solution.Methods： Orthogonal design method was employed to optimize the technique of preparation.Results： The best condition of preparation are described as following： the molar ratio of AM to β -CD in the inclusion complex should be 1： 1;the temperature should be 50℃ and the time of stirring should be 2 hours. Conclusion： The content of azithromycin in the inclusion complex preparing by this optimal technique was （18.87±0.25）%.