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冠心病患者外周血中sCD14水平的研究 被引量：1

A study on sCD14 levels in peripheral blood of patient with coronary heart disease
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摘要 目的分析冠心病患者外周血中sCD14的水平及其与单核细胞数量的相关关系,探讨sCD14和动脉粥样硬化之间的关系。方法ELISA法测定269例冠心病患者和24例健康人血清中的sCD14水平,血细胞分析仪检测受试者抗凝全血中单核细胞的数目和比例。结果冠心病患者与健康对照组sCD14分别为:(3 011.4±1431.4)ng/L和(1 943.8±510.2)ng/L,二者结果有显著差异(t=3.7259,P=0.002);冠心病患者血清sCD14水平(Y)与血单核细胞数量(X)和比例(X)均无相关关系,直线回归方程分别为:Y=2 969.8-95.6X,r=-0.026,P=0.668;Y=2 763.6+1581.8X,r=0.060,P=0.329。结论冠心病患者血清sCD14水平显著性增高与血单核细胞数量和比例均无相关关系,可能与单核细胞的质量改变有关。 Objective To study the quantity of sCD14 in peripheral blood of the patient with coronary heart disease（CHD）, and investigate the relationship between the source of sCD14 and the quantity of monocytes. Methods We studied sCD14 levels in serum of 115 patients with CHD by ELSIA Kit and compared with those of 24 healthy people as control group. The percentage and quantity of monocytes in these patients＇ blood were also tested by blood cell analyzer （Coulter STKS）. Results The sCD14 levels in the CHD patients were obviously higher than those in control group. There was no correlation between increased sCD14 and the quantity of monocytes. Conclusion 1. sCD14 levels in the blood of CHD patients were obviously high, which demonstrated that there is a close relationship between sCD14 levels and CHD. 2. The increased sCD14 in blood may be attributed to the changed quality of actived monocytes.
作者 张葵 王丽 罗浔阳 顾光煜 毕永春 宋景秋 夏永泉 郭丹 杜忠祥
机构地区 南京鼓楼医院检验中心
出处 《临床检验杂志》 CAS CSCD 北大核心 2005年第6期412-413,共2页 Chinese Journal of Clinical Laboratory Science
基金 南京市卫生局医学重点发展项目(YKKO344)
关键词 冠心病 可溶性CD14 动脉粥样硬化 单核细胞 coronary heart disease （ CHD ） sCD14 arteriosclerosis （AS） monocytes
分类号 R392.11 [医药卫生—免疫学]
  • 相关文献

参考文献5

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二级参考文献14

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共引文献12

同被引文献12

  • 1贺桦,许顶立,刘彦波,屠燕.慢性心力衰竭患者血清CRP水平的变化及临床意义[J].中国分子心脏病学杂志,2004,4(2):114-117. 被引量：13
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临床检验杂志
2005年 第6期

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