人类短串联重复序列VWA基因座的群体遗传学研究

POPULATION GENETICS OF SHORT TANDEM REPEAT LOCUS VWA

为了解不同群体中ＶＷＡ基因座等位基因和基因频率分布，作者应用自动激光荧光ＤＮＡ序列分析仪分析并构建了人类短串联重复序列ＶＷＡ等位基因分型标准物，用扩增片段长度多态技术分析了ＶＷＡ基因型及等位基因频率在中国和德国群体中的分布。计算了１７个群体间ＶＷＡ的遗传距离，并构建了系统树。结果表明ＶＷＡ系统树分析能够正确反映人种及种族间的遗传差异，为人类起源研究提供了新的参考资料。

The distributions of genotype and allele frequencies for the short tandem repeat locus VWA in Chinese and German populations were studied by amplified fragment length polymorphism analysis.Based on the allele frequencies of VWA,the genetic distances among 17 populations were computed and a phylogenetic tree was constructed accordingly,The results showed that the phylogenetic tree based on the allele frequencies of STR VWA locus can reveal not only the genetic variation between and within different racial groups but also the admixture resulting from migration of populations.