50350例正常儿童中筛查神经母细胞瘤

Early Screening of Neuroblastoma in Normal Children and Its Practical Clinical Significance

自１９８８年至１９９２年作者在国内首次采用ＳＰＯＴ点片法对辽宁地区部分正常儿童进行神经母细胞瘤（Ｎｅｕｒｏｂｌａｓｔｏｍａ，ＮＢ）的早期筛查。在５０３５０例正常儿童中，筛查出无临床症状的可疑患儿４例。此４例ＳＰＯＴ点片法均为阳性，层析结果分别出现香草扁挑酸（ＶＭＡ），高香草酸（ＨＶＡ），香早乳酸（ＶＬＡ）；ＶＭＡ定量超过正常值。经Ｂ超、磁共振检查，有３例在左肾上腺发现肿物，诊断为ＮＢ。另１例尚未确诊。初步得出辽宁地区小儿神经母细胞瘤的发病率约为６／１０万。

e undertook early screening of neuroblastoma(NB)in 50350 normal children,using urine spottest and two-dimensional paper chromatography,in Liaoning province from 1988 to 1992. Four NB pa-tients without any clinical slgns were found. Their urine spot tests were positive,Vanillyl-mandelic acid(VMA), homovanillic acid(HVA),and 3-methoxy-4-hydroxyphenyllactic acid(VLA) appeared respec-tively on chromatogram. Quantitative VMA was over normal value, By ultrasonoscope and MRI check-up, We found three of them had tumors on the left adrenal gland. The diagnosis for the fourth one wasnot yet established.The morbidity of NB was 6 in 100 000 in Liaoning province.