吸烟对肺癌的危险度及人群归因危险度的研究

The Study on the Risk and PAR of Cigarette Smoking to Lung Cancer

收集了有明确病理诊断的肺癌１０５６例，其中１０３５例有明确吸烟史、日吸烟量、吸烟年限等。同时按性别、年龄分层抽取同期非癌住院病人１１６例。结果：吸烟者患鳞癌、小细胞癌、大细胞癌的危险度（ＯｄｄｓＲａｔｉｏ，ＯＲ）分别为３．３０，（９５％ＣＩ／２．１２～５．１４）；２．９２（９５％ＣＩ１．６３～５．２２）；２．９７（９５％ＣＩ１．３６～６．５１）。与日吸烟量、吸烟年限均存在计量反应关系。吸烟与腺癌未见统计学联系，ＯＲ值为１．３４（９５％ＣＩ０．８５～２．１０）。为估计吸烟对沈阳地区各型肺癌发生的作用，研究了人群归因危险度（ＰｏｐｕｌａｔｉｏｎＡｔｔｒｉｂｕｔｅＲｉｓｋ，ＰＡＲ），鳞癌、小细胞癌、大细胞癌的ＰＡＲ值分别为０．４９、０．４４、０．４５。

ne thousand and fifty six cases of lung cancer which were identified pathologically Were dis-cussed.The sections were stained with HE,PAS-ab and Keratin. There were 1035 patients with lungcancer who had history of cigarette smoking at the same time.We collected 116 patients without malig-nant diseases by graduated sampling as their sex and age. The results showed that:The Odds Ratio(OR)values of squamous cell carcinoma,small cell carcinoma and large cell carcinoma cases withcigarette smoking were 3.30(95%CI 2.12～5.14),2.92(95%CI 1.63～5. 22)and 2.97(95%CI 1.36～6.51) respectively,All three types had dose- response relat ions with the amount and duration ofcigarette smoking,And adenocarcinoma did not relate to cigarette smoking,OR 1.34(95%CI 0. 85～2. 10).In order to estimate the effection of cigarette smoking with lung cancer in Shenyang city,popula-tion attribute risk(PAR)were calculated. PAR ofSquamous cell carcinoma,small cell carcinoma andlarge cell carcinoma are 0.49.0.44 and 0.45 respectively.