珊瑚奴卡氏菌致人膝关节膜炎首例报告

The First Case Report of Mocardia Corallina Leading to Gonarthromeningitis.

珊瑚奴卡氏菌引起膝关节、踝及小腿肌脓肿，大量积液，体温与白细胞升高等毒素反应，在脓液中直接纯分离到该菌，经手术排脓冲洗清净后闭式引流和敏感抗生素治愈，证实是该病灶的致病原菌。本分离菌细胞壁分型为Ⅳ型，细胞膜含有磷脂酰乙醇胺和枝菌酸。显微镜下能见稀疏的气生菌丝，基丝呈分叉状生长，２０ｈ开始断裂，形成微孢囊的生长周期，无分生孢子。水解酪氨酸、还原硝酸盐等项生化反应鉴定为珊瑚奴卡氏菌。

Nocardia corallina can lead to toxic reactions,such as abscess of knee joint,ankle joint, leg muscle;a great quantity of dydrops;body temperature and white blood cell elevations,Nocardia corallina is identified as the focus pathogen after surgical evacuation of pus,closed drainage and sensitive antibiotic therapy.The isolated fungus Nocardia corallina identified by cell wall is of type IV,the cell membrane consist of phosphatidylethanolamine and mycolic acid.A few scattered aerial mycelia can be seen microscopically and grow furcatedly,start breakdown after 20 hours,form nonconidiospore producing microsporangiospore,and they are the biochemical reactions of tyrosine hydrolysis and nitrate reduction.