摘要
目的使用功能性磁共振(fMRI)技术研究模拟失重状态对脑认知功能的影响。方法对8名青年航天训练志愿者进行卧床3周的模拟失重试验。试验前后使用fMRI对其进行脑认知功能测试。结果卧床前在完成执行功能任务时,所有受试者双侧额叶、扣带回和丘脑均出现显著激活,激活信号强度和范围与任务难度相关。卧床后完成相同任务时,激活脑区的范围减少,信号强度下降。卧床前后行为学数据变化无显著性差异。结论失重状态对兴奋脑区的血流动力学反应能力具有明确的负性影响,可能因而影响人脑的认知功能。
Objective To investigate the effect of simulated weightlessness nition. Methods Eight young male volunteers underwent -6° head-down bed on human brain cogrest （HDBR） for 3 weeks to simulate weightlessness. Functional magnetic resonance imaging during performing cognitive tasks was taken before and after HDBR. Results Before HDBR, significant activation in bilateral prefrontal, thalamus, and anterior cingulate gyrus during performing cognitive task was found. The signal intensity of brain activation map was correlated to task difficulty. After HDBR, the size and signal intensity of brain activation decreased obviously. No significant difference was found in the behavior data before and after HDBR. Conclusions Simulated weightlessness may exert negative effect on the homodynamic response of working brain, thus may affect the state of brain cognition.
出处
《中华航空航天医学杂志》
CSCD
2005年第3期161-164,F0004,共5页
Chinese Journal of Aerospace Medicine
关键词
功能性磁共振
失重模拟
认知
Functional magnetic resonance imaging
Weightlessness simulation
Cognition
