扶正抑瘤颗粒对食管癌组织细胞周期及NF-κB影响的临床观察

Clinical Observation on Effect of Fuzhengyiliu Granules on cell cycle and NF-κB in tissue of esophageal carcinoma

目的观察扶正抑瘤颗粒对食管癌患者肿瘤组织细胞周期及核转录因子NF-κB的影响。方法68例食管癌患者随机分为治疗组和对照组,治疗组服用扶正抑瘤颗粒15 d后手术,取两组患者手术切除的肿瘤组织,检测细胞周期和NF-κB。结果治疗组较对照组NF-κB明显升高(P<0.05);肿瘤细胞G0/G1期比率明显升高(P<0.01),S期比率明显降低(P<0.01);治疗组凋亡率与对照组比较差异有显著性(P<0.001)。结论扶正抑瘤颗粒可提高肿瘤细胞NF-κB的表达,阻止肿瘤细胞增殖,促进肿瘤细胞凋亡。

Objective To observe effect of Fuzhengyiliu factor-kB （NF-kB） in tissue of esophageal carcinoma. Method Granules on cell cycle To divide randomly 68 and nuclear transcription patients with esophageal carcinoma into two groups. The treatment group was given Fuzhengyiliu Granules for 15 days and then the operations were performed in two groups respectively. The cell cycle and NF-kB in tumour tissue of the patients in two groups were examined. Result The level of NF-kB in the treatment group was significantly increased than that in the control group （P 〈0.05）. The ratio of G0/G1 stage cells were significantly increased （P 〈0. 01 ） and that of S stage cells significantly decreased （P 〈 0. 01 ） in the treatment group. At the same time there was a significant difference in cell apoptosis rate between two groups （ P 〈0. 001 ）. Conclusion Fuzhengyiliu Granules can increase the NF-kB expression, block the proliferation and promote the apoptosis of tumour cells.