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慢性心力衰竭血清sFas、外周血单个核细胞凋亡与心功能及中医证型的关系 被引量:2

Relationship between Serum sFas, Apoptosis of PBMC and CHF, TCM Differentiation
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摘要 观察慢性心力衰竭(CHF)患者外周血单个核细胞(PBMC)凋亡及血清可溶性Fas(sFas)水平与心衰程度的关系及与心衰中医证型的关系。结果显示:①CHF患者sFas、PBMC凋亡率较正常明显升高(P<0.01);②阳虚水泛组与心肺气虚组相比,血清sFas、PBMC凋亡率均明显增高(P<0.05);③血清sFas与PB-MC凋亡率与心功能分级呈负相关。结论:①心功能分级与血清sFas与PBMC凋亡率呈负相关;②血清sFas、PBMC凋亡率水平可能是CHF患者出现不同中医证型的内在因素之一。 To observe the relationship between apoptosis of peripheral blood mononuclear cells (PBMC), serum soluble Fas (sFas) in chronic heart failure (CHF) and the degree of heart failure, the TCM differentiation of CHF. Result: ① Serum sFas, apoptotic rate of PBMC in CHF were greatly increased compared with healthy con- trol(P 〈0.01 ). ②These index in edema of yang deficiency group were obviously higher than that of in heart-lung qi deficiency group (P 〈 0.05 ). ③There are negatively correlation between serum sFas, apoptotic rate of PBMC and the New York Association classification of heart function. Conclusion: ① Classification of heart function is negatively correlated with serum sFas and the apoptotic rate of PBMC. ② Serum sFas and the apoptotic rate of PB- MC may he one of the factors which lead to different TCM differentiation in the patients with CHF.
出处 《福建中医学院学报》 2005年第6期1-3,共3页 Journal of Fujian College of Traditional Chinese Medicine
基金 福建省教育厅科研基金资助项目(JB03200)
关键词 心力衰竭 细胞凋亡 SFAS heart failure apopotosis sFas
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