出血性中风中经络血清sICAM-1、MDA变化的临床研究

Clinical Study of Change on Serum sICAM-1 and MDA in Patients with TCM Syndrome Types of Apoplexy Involving Channels and Collaterals with Acute Intracerebral Hemorrhage

探讨急性脑出血中医各证型血清可溶性细胞间粘附分子(sICAM-1)和丙二醛(MDA)含量变化及意义。采用双抗体夹心酶联免疫吸附(ELISA)法、硫代巴比妥酸(TBA)法分别测定64例急性脑出血患者和20例健康人血清中sICAM-1、MDA的含量。结果:急性脑出血患者血清sICAM-1、MDA含量明显升高,以痰热腑实组升高最为显著。结论:急性脑出血白细胞粘附、机体氧化应激增强,患者血清sICAM-1、MDA明显升高,二者关系密切,参与了脑出血后脑损伤的病理过程,以痰热腑实证为最明显。

To explore the changes and their significance of serum soluble intercellular adhesion molecute-t （sICAM-1） and malondialdehyde （MDA） contents in patients with acute intracerebral hemorrhage （AICH） of different TCM syndrome. Serum slCAM-I and MDA contents were determined respectively by double antibody sandwich enzyme-linked immunosorbent assay （ELISA） and thiobarbituric acid （TBA） in 64 cases of AICH and 20 healthy people. Results： Serum sICAM-1 and MDA contents increased significantly in patients with AICH. A- mong the various groups of involving channels and collaterals, the two indexes of phlegm-heat and fu-organ excess group increased most obviously. Conclusion ： Strengthening of leukocyte adherence and oxidative stress in patients with AICH are closely related to the increases of serum sICAM-1 and MDA, which participate the pathological course of cerebral injury after cerebral hemorrhage. It is the most remarkable in phlegm-heat and fu-organ excess group.