不同证型急性心肌梗死红细胞免疫变化的初步研究

The Primary Research on the Red Blood Cell's Immune Variety of Patients with AMI,Variable Syndromes in TCM

目的从红细胞免疫角度探讨急性心肌梗死(AMI)中医证型的分子生物学机制。方法测定AMI各中医证型患者红细胞C3b受体花环率(RBC-C3bRR)及红细胞免疫复合物花环率(RBC-ICR),并与健康人比较(对照组)。结果AMI不同证型组与对照组的RBC-C3bRR相近,RBC-ICR则明显高于对照组,以阳脱阴竭组及心阳虚衰寒凝心脉组为甚。结论免疫损伤、红细胞免疫复合物增高参与AMI病理发展过程。RBC-ICR可作为预测和诊断AMI的重要辅助指标,为中医辨证施治提供客观依据;而提高AMI患者红细胞免疫功能,对救治及提高生存率有一定意义。

Objective:To discuss molecular biology machanism of AMI's syndrome types in T CM from the point of the BRC's immune.Methods:To measure RBC's immune function i n surrounding blood when AMI.To measure the BRC- C3 BRR and the RBC- ICR by GU O- FENG improvedd way.Result:The BRC- C3 BRR's comparison between the group o f AMI's various syndrome types and the control group had no significant differen ce but the RBC- ICR of the group of AMI's various syndrome types were obviously higher than those in the control group respectively,the groups of syndrome type s of Yang Delpletion and Prolapse of the Uterus,Declination of Heart Yang,Stagna tion of Cold in the Vessel in the Heart had exetremly obvious difference.Conclus ion:Immune injury and the increase of BRC's immune complex join the pathological progress of AMI.RBC- ICR can be a important assistant guideline and have some definite effect to cure AMI and improve the rate of survival.