摘要
本实验在狗“二次蛛网膜下腔出血”模型上分别观察了７６４－３对血管痉挛的直接作用和对慢性脑血管痉挛的预防作用。结果表明：推荐剂量（２ｍｇ／ｋｇ，静注）的７６４－３对动脉血管无直接扩张作用。通过７６４－３的连续预防用药（４０ｍｇ／ｋｇ·日，肌注）能减轻慢性脑血管痉挛的程度（Ｐ值＜０．０５），降低动脉壁的过氧化脂质（Ｐ值＜０．０５），同时对全身血压、心率及白细胞数无不良影响。本文对上述结果进行了讨论。
A″double-SAH' dog modle was adopted to study the direct effect of 764-3 on cerebral vasspasm(CVS) and its preventive effect on chronic CVS. The results showed: No dilating change of basilar artery(BA)was observed when 764-3 was given intravenously with the dosage of 2mg/kg, while the preventive application of 764-3(40mg/kg·day, im)initiated on first day CVS( P<0. 05)and reduce LPO content of BA wall(P<0.05)without any side effect on blood pressure, heart rate and number of WBC in circulating blood. The significance of the results was discussed.
出处
《中华神经外科杂志》
CSCD
北大核心
1996年第3期174-176,共3页
Chinese Journal of Neurosurgery
基金
卫生部科研基金
