急性心肌梗塞患者体内维生素E与脂质过氧化的关系

Lipid peroxidation and serum vita ine E levels in patients with acute myocardial infarction

检测１２例急性心肌梗塞（ＡＭＩ）、２１例冠心病（ＣＡＤ）和２０例正常对照（ＮＳ）的血清维生素Ｅ（ＶｉｔＥ）、人超氧化物岐化酶（ｈＳＯＤ－１）及血浆过氧化脂质（ＬＰＯ）的代谢产物之一丙二醛（ＭＤＡ）水平。结果显示ＡＭＩ组的ＭＤＡ水平明显高于ＣＡＤ及ＮＳ组，而ＶｉｔＥ水平则显著低于ＣＡＤ及ＮＳ组，二者呈显著负相关（γ＝－０．６７，Ｐ＜０．００１）；ＡＭＩ和ＣＡＤ组的ｈＳＯＤ－１水平均明显低于ＮＳ组，但其两组间无差异，提示ＡＭＩ时ＶｉｔＥ作为主要的抗氧化剂被大量消耗，可能是ＡＭＩ发展的原因之一。

The levels of serum vitamine E (Vit E), Cu-Zn-Superoxide dismutase (Cu-Zn-SOD) ,and malonaldehyde (MDA) had been compared among the groups of normal subjects (NS,20 cases).patients with coronary artery disease (CAD,21 cases) and with acute myocardial infarction (AMI,12 cases);The results showed that:1.the levels of MDA in AMI group were much higher than in CAD and NS groups(P<0.001),but the levels of Vit E in AMI group was lower than in CAD and NS groups(P<0.001).There was significant negative correlation between the levels of Vit E and MDA in AMI group (r=-0. 67,P<0. 001).2. the levels of Cu-Zn-SOD in AMI and CAD groups were lower than in NS group (P<0. 05),and no significant difference was found between AMI and CAD groups. The data above indicated that :as a cleaning agent of oxygen free radical in vivo,Vit E played more important role than Cu-Zn-SOD during the ongoing of acute myocardial infarction.