慢性肺心病病人内皮素及超氧化物岐化酶的变化

Changes of Plasma Endothelin and SOD Levels in Patients with Chronic Cor Pulmonale

慢性肺心病患者由于缺氧和高碳酸血症,血浆超氧化物岐化酶(SOD)降低,肺血管内皮和支气管内皮细胞释放内皮素(ET)增多。用放射免疫分析法测定了33例慢性肺心病患者治疗前后及21例健康人的SOD和ET水平,并与动脉血气指标作了相关分析。结果显示:肺心病组治疗前ET明显高于对照组(P<0.01),SOD明显低于对照组(P<0.01)。治疗后ET较治疗前降低(P<0.05),但仍明显高于对照组(P<0.01)。治疗前ET与PaO_2呈显著负相关(P<0.01),ET与PaCO_2呈显著正相关(P<0.01),而与pH值无相关。治疗前SOD与PaO_2及pH值呈显著正相关(P<0.05),与PaCO_2呈负相关(P<0.05)。治疗后ET和SOD与PaCO_2、PaO_2及pH值无相关关系。

Plasma endothelin(ET)and SOD levels were mearsured with radioimmunoassay in 33 patients with chronic cor pulmonale before and after treatment. The results showed that ET level was significantly higher before treatment and decreased after treatment(P<0. 01) ,but it was still higher than that of controls (P<0. 01). SOD level was significantly lower in cor pulmonale patients (P<0. 01). There was negative correlation between PaO2 and ET levels before treatment, but there were positive correlations between PaCO2 and ET levels and between PaO2, pH and SOD (P<0. 05). A negative correlation presented between PaCO2 and SOD (P<0. 05). There were no-correlations between PaCO2,PaO2,pH and ET,SOD after treatment.