摘要
目的：研究周围型肺癌Ｐ５３蛋白异常表达与ＣＴ表现的关系。材料与方法：应用链菌素亲生物素－过氧化酶连接法及快速免疫组化染色检测和高分辨率ＣＴ扫描，对６１例经病理证实的周围型肺癌Ｐ５３蛋白异常表达与ＣＴ征象之间的关系进行了探讨。结果：肺癌Ｐ５３蛋白异常表达阳性与肿瘤分化程度、恶性度和ＣＴ表现有关。结论：ＣＴ表现肺癌瘤体≥３ｃｍ、深分叶、棘状突起、伪足征、肿瘤强化、ＣＴ值≥４１ＨＵ、有淋巴结转移者与Ｐ５３蛋白异常表达有关。
Purpose:ToresearchtherelationshipbetwentheCTappearanceandP53abnormalexpressionofperipherallungcancer.Materialsandmethods:ThestreptavidinperoxidaseconjugatedmethodandarapidimmunohistochemicalmethodandHRCTwereusedinthisstudytodetectthere-lationshipbetwentheCTappearanceandP53abnormalexpressionin61casesofperipherallungcancerprovedbypathology.Results:P53abnormalexpressionoflungcancercorrelatedwiththede-greeofthetumorceldiferentiationandmalignancy,thelymphonodimetastasisandtheCTappear-anceofperipherallungcancer.Conclusion:Theappearanceoflungcancerwithadiametermorethan3cm,deeplobulation,spiculatedprotuberance,pseudo-footsign,thecontrastenhancementscanningdensityoftumor(>41HU)andlymphnodemetastasiswasrelatedtotheabnormalexpresionofP53(P<0.001).
出处
《中华放射学杂志》
CAS
CSCD
北大核心
1996年第4期261-264,共4页
Chinese Journal of Radiology
关键词
肺肿瘤
病理学
CT
P53蛋白
LungneoplasmsPathology,clinicalTomography,X-raycomputed
