青海高原汉族人群ACE基因多态性频率的观察

Polymorphism of angiotensin-converting enzyme genein Qinghai Han nationality

目的探讨血管紧张素转换酶(ACE)基因插入/缺失多态性在高原汉族人群中的频率分布以及高原汉族人群和平原汉族人群的ACE多态性频率的比较.方法用聚合酶链式反应(PCR)法对高原地区汉族人群进行ACE I/D基因型的分析.结果高原地区汉族的ACE基因型频率分布是,Ⅱ型0.467I、D型0.40、DD型0.134,与平原汉族比较基因型频率无显著差异.结论高原汉族人群和平原汉族人群在ACE基因多态性的频率分布无明显的地区差异,与国外其它种族差异显著.

Objective：To investigate the distribution of angiotensin converting enzyme（ACE）gene insert/deletionpolymorphism in Qinghai Han nationality and compare Qinghai high altitude Han nationality with low altitude of ACE gene polymorphism frequency. Methods： A polymerase chain reaction（PCR） for ACE gene polymorphism analyze of Qinghai Hart. Results： The frequencies of the DD, IDand 11 genotype were 0. 134,0.40 and 0.467 respectively, The Qinghai Han nationality frequencies of three genotype haden＇ t obviously differences with lower high altitude Hanna-tionality （P 〉0. 05）. Conclusion： These results suggest that there aren＇t significant differences in the distribution of ACE genotyped freqences between the high altitude Hart nationality and lower high altitude but have significant differences of ACE gene genotyped freqences for overseas population.