赤芍、尼群地平对家兔实验性动脉粥样硬化病灶的消退作用

Effect of nitrendipine and radix paeoniae rubra on regression of atherosclerosis in rabbits

雄性大耳白兔２５只，采用免疫损伤合并高胆固醇（１％）喂饲４０天，造成动脉粥样硬化（ＡＳ）模型，然后随机分四组：模型组（Ｍ组）立即处死；对照组（Ｃ组）喂普通饲料；治疗组又分两组，均喂普通饲料７５天，其中尼群地平组（Ｎ组）同时每天每只口服尼群地平４０ｍｇ，赤芍组（Ｐ组）同时服赤芍煎剂（按每千克体重每天含生药１０ｇ配制）。结果：各组主动脉ＡＳ病灶面积百分比为：Ｍ组５８．１％，Ｃ组６８．１％，Ｎ组２７．５％，Ｐ１９．６％；各组冠状动脉ＡＳ病灶面积百分比分别为：Ｍ组６０．６％，Ｃ组４３．５％，Ｎ组１９；７％，Ｐ组２６．６％。提示尼群地平、赤芍可促进ＡＳ病灶的消退。

Twenty-five male rabbits were injured with immunoreaction and fed a 1% cholesterol diet for forty days,then they were divided into four groups.Rabbits in M group were killed immediately,those in other three groups were fed with stock diet for seventy-five days(C group),only those in N group added nitrendipine(NT) 40 mg daily,those in P group added radix paeoniae rubra(RPR)10g·kg-1/L daily. The results showed that percentage of surface of aortic atherosclerosis lesion was:M 58.1%,C 68.1%,N 27.5%,P 19.6%;pescentage of surface of coronary arteries atherosclerosis lesion was: M 60.6%、C43.5%、N 19.7%、P26.6%.This study suggested NT and RPR could regress atherosclerotic lesion.