抗人成骨肉瘤单克隆抗体对人骨肿瘤定位显像的临床应用

TheClinicalApplicationsofImmunoscintigraphyUsingAnti┐osteogenicSarcomaMonoclonalAntibodyinHumanBoneTumors

作者使用１３１Ｉ标记抗人成骨肉瘤单克隆抗体（ＯＳＭｃＡｂ－Ｂ４）对１１例骨肿瘤及１例慢性骨髓炎患者进行肿瘤定位显像。６例成骨肉瘤和１例胚胎型横纹肌肉瘤呈阳性显像，骨软骨瘤、巨细胞瘤及骨髓炎等均呈阴性。结果证实ＯＳＭｃＡｂ－Ｂ４对成骨肉瘤组织有较好的特异性，使用核素标记该抗体对骨肿瘤进行放射免疫显像，是目前诊断成骨肉瘤较特异。

Immunoscintigraphyusingradioisotope-labeledmonoclonalantibody(OSMcAb-B4)preparedagainsthumanosteosarcomawasusedtodetect12patientswithknownorsuspectedbonetu-mors.Theywerevisualizedinsitubygamma-cameraimagingat48or72hoursafteradministrationof131I-labeledanti-osteogenicsarcomamonoclonalantibodyOSMcAb-B4.Sixcaseswithosteosarco-mahadpositiveimages.Theotherpatientswithosteochondroma,osteomyelitisetc.hadnegativeim-ages.ThepresentresultsilustratedthatthebindingofOSMcAb-B4toosteosarcomatissueswasaspecificphenomenon.Theradioimmunodetectionusingradioisotope-labeledOSMcAb-B4inhumanbonetumorsisaspecificandefectivemethodforthedetectionofosteogenicsarcoma.