摘要
The effects of different matrix material content s on the release of soluble drug’s mixed matrix were studied.With dissolu tion as guideline,and Captopril as model drug the effect of matrix material cont ents on the release of Captopril from hydrophilic gel matrix, wax matrix and mix ed matrix were compared.The content of the matrix material had greater influence on the release of Captopril from mixed matrix than that from former single matr ix. Moreover, the effect of Compritol 888 contents was more significant than th at of HPMC K4M in mixed matrix.
The were studied. contents on th compared. Th effects of different matrix material contents on the release of soluble drug＇s mixed matrix With dissolution as guideline, and Captopril as model drug the effect of matrix material e release of Captopril from hyd e content of the matrix material h rop ad hilic gel matrix, wax matrix and mixed matrix were greater influence on the release of Captopril from mixed matrix than that from former single matrix. Moreover, the effect of Compritol 888 contents was more significant than that of HPMC K4M in mixed matrix.
出处
《化工学报》
EI
CAS
CSCD
北大核心
2005年第10期2024-2028,共5页
CIESC Journal
