宽舌橐吾的化学成分研究(Ⅱ)

Chemical Constituents of Ligularia platyglossa(Ⅱ)

目的: 研究宽舌橐吾(Ligularia platyglossa (Fr.) Hand.-Mazz.)的化学成分,寻找生物活性物质,为橐吾属化学分类研究和资源开发利用奠定基础.方法:采用硅胶柱、Sephadex LH-20柱和RP-C18柱层析法分离、重结晶纯化化合物,根据理化性质、标准品薄层对照、波谱数据和单晶X-ray衍射分析鉴定化合物结构.结果:从宽舌橐吾的地下部分分得5个化合物,分别鉴定为1, 8-Dihydroxy-eremophil-7(11),9(10)-dien-12,8-olide(1);1-Oxo-8-hydroxy-10H-eremophil-7(11)-en-12,8-olide(2);9β, 9′β-Bis-1, 8-dihydroligularenolid(3);9β, 9′α-Bis-1, 8-dihydroligularenolid(4);羽扇豆醇(lupeol)(5).结论:化合物1为新化合物,化合物2～4为首次从橐吾属中分得,化合物5为首次从宽舌橐吾中分得.

AIM： To find bioactive compounds from Ligularia platyglossa. METHOD： Compounds were isolated by silica gel, Sephadex LH-20 and RP-18 column chromatography and purified by recrystallization. Their structures were identified by NMR spectra and single crystal X-ray diffraction analysis. RESULT： Five compounds were isolated and identified as 1,8-Dihydroxy-eremophil-7 （11）, 9 （10）-dien-12,8-olide（1） ; 1-oxo-8-hydroxy-10H-eremophil-7（ 11 ） -en-12,8-olide （2） ; 913, 9＇β-Bis-1, 8-dihydroligularenolid （3） ; 9β,9＇ α-Bis-1, 8-dihydroligularenolid （4）; lupeol（5）, respectively. CONCLUSION： Compound 1 was a new eremophilenolide. Compound 2 ～ 4 were isolated firm Ligularra genus for the first time and compound 5 was isolated from this plant for the first time.