肾综合征出血热患者血清sP-选择素动态观察及临床意义

Determination and clinical significance of soluble P-selection in patients with hemorrhagic fever with renal syndrome

目的探讨肾综合征出血热(HFRS)患者血清可溶性P选择素(sP-选择素)水平的动态变化情况及其临床意义。方法用ELISA检测25例正常人和39例EHF患者四期(发热期、少尿期、多尿期及恢复期)血清sP-选择素水平。结果(1)EHF患者血清sP-选择素水平明显升高,且重症组高于轻症组；(2)少尿期及多尿期血清sP-选择素与血尿素和血肌酐均呈显著正相关(P＜0.01),血清sP-选择素与外周血血小板数呈显著负相关(P＜0.01)。结论血清sP-选择素作为重要的免疫分子参与HFRS的发病过程,动态检测HFRS患者血清sP-选择素水平,可作为HFRS病情观察的重要指标,同时也可为HFRS发病机制及防治研究提供线索。

Objective To observe the change of serum levels sP-selectin in patients （HFRS） and the clinical significance. Methods The serum levels of sP-selectin were measured by EI.ISA in 39 patients HFRS and 25 normal people. Results 1. The average serum level of sP-selectin was higher in patients with HFRS, furthermore the levels of those in the severe group were higher than in light group; 2. the concentration of sP-selectin was remarkable positively correlated with serum levels of CRE and Urea（P〈0. 01）, while sP-selectin was remarkable negatively correlated with the number of peripheral blood platelets （P〈0. 01） in patients at oliguria and polyuria phase. Conclusion sP-selectin as important immunological molecule take part in the occurrence course of HFRS, and it could be a important observation index.