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红细胞压积作为大鼠重症急性胰腺炎早期预测指标的探讨 被引量:1

Study of Hematocrit as a predictable marker for Early Severe Acute Pancreatitis
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摘要 目的探讨红细胞压积作为大鼠重症急性胰腺炎(SAP)早期预测指标的可行性,为临床应用提供动物试验依据。方法将32只Wistar大鼠随机均分为四组:假手术组(SO)、轻型急性胰腺炎组(MAP)、重症急性胰腺炎纽(SAP)和SAP补液治疗组(补液组),后三组简称胰腺炎组。每组均在术后2、7和12小时抽血查AMY、HCT值,并于术后12小时杀活大鼠,取心、肺、肝、肾、胰进行病理检查,比较四组血HCT变化规律,胰腺和重要脏器损伤程度。结果(1)SAP组HCT三时间点之间比较差异有统计学意义(P<0.05),离手术时间越长,HCT值越大。(2)补液组中,HCTl2小时比2小时显著降低(P<0.01)。(3)SAP组的HCT比SO、MAP组、补液组明显增高(P<0.01)。(4)SO、MAP组大鼠无重要脏器损伤,而SAP组部分大鼠合并有重要脏器损伤,尤其以肺和肝较多见;补液治疗能减少重要脏器损伤数目,降低死亡率。结论HCT能作为早期预测SAP的指标;补液治疗能降低HCT,并能减少重要脏器的损伤,降低死亡率,改善预后。 Objective To study the feasibility of hematocrit (HCT) as a predictable marker for early severe acute pancreatitis. Methods 32 healthy Wistar rats were randomly divided into 4 groups. Sham operative group (SO), mild acute pancreatitis group(MAP), severe acute pancreatitis group (SAP) and liquid therapy group that each group were divided into 2h, 7h, 12h sub-group again. After models were induced, the serum concentration of amylase (AMY), HCT were tested and observed of pathologic result of the heart, lung, liver, kidney and pancreas. Results (1)HCT had apparently increase in SAP 7h,12h sub-group compared to 2h ( P〈0. 01), and HCT also had apparently increase in SAP 12h sub-group compared to 7h ( P〈0. 01). (2)In liquid therapy group, HCT had decrease compared 2h to 12h(P〈0. 01). HCT increase significantly in SAP group, compared to SO, MAP, and liquid therapy group respectively (P〈0. 01). (3)Wistar rats bad no important organ injury in SO, MAP groups, but had some important organs injury in SAP group. Conclusion HCT was an important early predictable marker for SAP.
出处 《贵州医药》 CAS 2005年第12期1076-1078,共3页 Guizhou Medical Journal
关键词 重症急性胰腺炎 红细胞压积 预测指标 Severe acute pancreatitis Hematocrit Predictable marker
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