脑深部电刺激术（DBS）治疗帕金森病

Deep Brain Stimulation in the Treatment Of Parkinson＇s Disease

目的 研究脑深部电刺激（DBS）冶疗帕金森病的手术方法和疗效。方法 对具有双侧症状的46例原发性帕金森病患者进行同期双侧丘脑底核（STN）电刺激术治疗，采用MRI扫描结合术中微电极记录技术进行靶点定位，术前、术后UPDRS运动评分评价手术疗效。结果 全部46例帕金森病患者术后震颤、僵直及行动迟缓均有不同程度改善，UPDRS评分“关”状态平均改评善率为635％；“开”状态平均改善率为26.4％。术后随访1年症状仍有持续性改善，未发现任何严重永久性并发症。结论 脑深部电刺激术可明显改善帕金森病的主要症状，是目前治疗帕金森病的最佳方法。

Objective： to investigate the effeeting or deep brain stimulation in the treatment of Parkinson＇s disease. Methodss： 46 patients with Parkinson＇s disease underwent the bilateral surgery of STN deep brain stimulation. Using MRI scan for imaging-based anatomic targel and target, contrasting the score of UPDRS between pre-operalion and post-operation to evaluate the effect. Results： All the patients have the obviously improvement to the main symptom （including tremor rigidity and dyskinesia）, Scores of UPDRS descended significantly after DBS（P〈0.01）, the improvement rate are separately 63.5% in the “off” states and 26.4% in the “on” state. The symptom continuous improved and no severe complication were found follow-up visit one year after operation. Conclusions DBS can obviously improve the main symptoms of Parkinson disease, and is the best way in the treatment of Parkinson disease.