感染性肠炎患儿血IL-18、CRP和IL-6检测的临床意义

Detection of IL-18,CRP and IL-6 in enteritis children with various pathogens and its clinical significance.

目的探讨不同病原体肠炎患儿血IL-18、CRP和IL-6的检测及其临床意义。方法对确诊的32例细菌性肠炎患儿、30例病毒性肠炎患儿及体检正常的30例小儿的血IL-18、CRP、IL-6进行检测。结果细菌性肠炎组患儿血IL-18、CRP、IL-6分别为(200·19±29·53)ng/L、(31·41±13·65)mg/L、(297·13±51·42)ug/L。病毒性肠炎组患儿分别为(60·80±13·32)ng/L、(11·53±3·59)mg/L、(28·27±15·69)ug/L。对照组患儿分别为(54·47±11·62)ng/L、(8·45±1·92)mg/L、(17·30±4·72)ug/L。细菌性肠炎组IL-18、CRP、IL-6均升高(P<0·01),而病毒性肠炎组升高不明显,与对照组相比差异无统计学意义(P>0·05)。结论血IL-18、CRP、IL-6检测对鉴别小儿肠炎的病原体有重要临床意义。

Objective To study the clinical significance of serum interleukin - 18（IL- 18）,C - reactive prutein（CRP） , inter- leukin- 6（IL- 6） in children with enteritis caused by pathogenic microorganism. Methods Serum IL- 18 , CRP, IL- 6 were measured in 32 patients with bacterial enteritis,30 patients with viral enteritis and 30 children with no enteritis as were taken as control. Results The level of serum IL- 18,CRP,IL- 6 was 200.19 ± 29.53ng/L,31.41 ± 13.65mg/L,297.13 ± 51.42 ug/L, respectively in the bacterial enteritis group.In the viral enteritis group it was 60.80 ± 13.32ng/L, 11.53±3.59mg/L,28.27 ± 15.69 ug/L respectively. In the control group it was 54.47 ± 11.62 ng/L,8.45 ± 1.92mg/L,17.30 ± 4.72ug/L, respectively. IL- 18, CRP,IL- 6 concentration in patients with bacterial enteritis were significantly higher than the other patients with viral enteritis and the contrul （P 〈 0.01）, whereas there were not statistically different between the viral enteritis group and the control. Conclusion Serum IL- 18,CRP,IL- 6 is of importance in the diagnosis of enteritis caused by pathogenic microorganism.