小鼠伍用氯胺酮与赛拉嗪翻正反射和毒性的影响

Combined effects of ketamine and xylazine on righting reflex and toxicity in mice

观察了氰胺酮（Ｋｅｔ）与赛拉嗪（Ｘｙ１）以１：１和３：１配伍对小鼠急性毒性和翻正反射消失效应的影响。用Ｑ（ｘ）统计检验合用后的联合作用性质，并绘制出Ｑ曲线及其９５％可信限图．可见Ｋｅｔ与Ｘｙｌ以１：１和３：１伍用后毒性分别为相加和轻微协同，翻正反射消失效应均呈协同性增强．配伍后的治疗指数，安全指数及可靠安全系数都较单药提高．大鼠和大的实验结果也表明Ｋｅｔ与Ｘｙｌ伍用后效应增强．

The effects of ketamine(Ket).xylazine(Xyl)and their combination on toxicity andloss of righting reflex were evaluated by Q(x)method. The LD50 of Ket and Xyl were 356 mg·kg-1 and 109mg·kg -1.and the ED50 of Ket and Xyl leading to lossof righting reflex were 103 mg· kg-1 and 43 mg·kg-1 respectively . The results also suggested that theCombined effects of Ket and xyl on toxicity with dose separately.ralio 1:1 and 3:1 were additive(1:1,LD50=164 mg·kg-1)and synergetic(3:1,LD50=200 mg·kg-1)respectively,while those on loss of righting reflexwith same dose ratios as above were all synergetic(1:1, ED50=21 mg·kg-1 and 3:1,ED50= 20 mg·kg-1). The therapeutic index,safety index and certainsafety factor of Ket and Xly combination were remarkably higher than those of Ket or Xyl administratedseparately.