摘要
小檗碱５，１０，２０ｍｇ·ｋｇ－１ｉｐ可显著延长双侧颈总动脉结扎致脑缺血小鼠的存活时间。自颅外阻断大鼠大脑中动脉造成局灶性脑缺血模型。小檗碱２０，４０ｍｇ·ｋｇ－１于术前中，能缩小缺血２ｈ造成的梗塞范围，减轻神经功能障碍．小檗碱４０ｍｇ·ｋｇ－１ｉｐ能提高大鼠急性脑缺血３０ｍｉｎ时的血浆，海马及皮层脑组织的超氧化物歧化酶活力。降低丙二醛含量。结果表明。小檗碱对缺血脑组织有保护作用。其机理推测与其抗氧自由基损伤有关．
erberine(Ber 5,10、20mg·kg-1,ip)significantly prolonged the survial time of
micesubjected to cerebral ischemia by the occlusion of thebilateral carotid arteries. The
mortality of the mice sub-jected to reperfuSion after cerebral ischemia was re-duced by Ber
After acute incomplete cerebral ischemiain rats induced by hypotension coupled
withhypoperfusion for 30 min, Ber (40 mg·kg -1 ip) mightmarkedly increase the activities of
superoxidedismutase and decrease the concentration ofmalndialdehyde in plasma,as well as
in hipocampusand cortex of the brain.in the model of local cerebralinfarction of rat produced by
middle cerebral arteryocclusion,Ber(20, 40 mg·kg-1,ip before operation)decreased the infarct
size and ameliorated neurologicdeficits,improved electroencephalogram changes in 2h
occ1usion of rats.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1995年第2期100-103,共4页
Chinese Journal of Pharmacology and Toxicology
关键词
小檗碱
脑缺血
超氧化物歧化酶
berberine
cerebral ischemia:superoxide dismutase,cerebral
infarction
