西洋参根粗多糖对免疫功能低下小鼠免疫功能的影响

Effects of CPPQ on immunologic function of immunosuppressive mice induced with cyclophosphamide

本实验在环磷酰胺免疫功能低下小鼠模型、观察了ＣＰＰＱ对小鼠外周血白细胞总数，胸腺和脾脏重量，网状内皮系统吞噬能力及细胞免疫功能的影响。结果表明，ＣＰＰＱ不仅能抗免疫功能低下小鼠外周血白细胞减少及胸腺和脾脏重量的减轻，并能增强正常和免疫功能低下小鼠网状内皮系统的吞噬功能。同时能促进免疫功能低下小鼠的淋巴细胞转化，而对白细胞介素Ⅱ活性无明显影响。

This paper investigated the effects of CPPQ on the WBC numbers,thymus and spleenweight, phagocytosis of reticuloendothelial system and cell-mediated inimunity of mice using the im-munosuppresive mice model induced with cyclophosphamide.It was found that CPPQ not only couldoppose leukopenia of surrounding blood but also could increase the weight of thymus and spleen in im-munosuppresive mice,and strengthen phagocytosis of reticuloendothelial system in normal and im-munosuppresive mice.At the same time,CPPQ could improve lymphocyte transformation and had noobvious effects on IL一2 activity in immunosuppresive mice.