摘要
目的:探讨正常大小卵巢癌综合征(normal-sized ovary carcinoma syndrome,NOCS)的临床特点、诊断标准、有效的治疗方法及预后.方法:回顾性分析1991~2000年在二院治疗及病理复核证实的22例正常大小卵巢癌综合征,均为二院首诊患者,其中9例为性腺外苗勒氏管肿瘤,也称卵巢外腹膜浆液性乳头状腺癌(The extraovarian peritoneal serouspapillary carcinoma,EPSPC),1例原发灶不明的转移性腺癌(疑为EPSPC),7例卵巢浆液性囊腺癌,3例子宫内膜样腺癌,2例透明细胞癌.上述无论何种类型,均最大限度手术切除肿瘤病灶,术后残存肿瘤尽可能<2 cm,多数辅以有效多疗程联合化疗.结果:1例EPSPC存活90个月,随访至2004年10月仍健在.1例双卵巢浆液性囊腺癌已存活92个月,随访至2004年11月仍健在,另1例为子宫内膜样腺癌为76个月,目前仍健在.8例已死亡EPSPC患者平均生存12.8个月,比文献报道存活时间略长.结论:对此综合征患者尤其EPSPC患者,必须高度重视鉴别诊断,首选手术治疗,尽量切除癌灶(残存肿瘤<2 cm),术后辅以有效化疗或放疗,以期获得最佳生存和预后.
Objective: To evaluate clinical -pathologic features, diagnostic criteria, effetctive treatment and prognosis of a clinically rare normal -sized ovary carcinoma syndrome. Methods: Histologie slides of 22 cases from 1991 to 2000 of normal -sized ovary carcinoma syndrome were retrospectively reviewed. Nine of the 22 cases were extraovaria peritoneal serous papillary carcinoma (EPSPC) . The remaining 13 cases were serous adenoeareinoma of the ovary (7 cases) , endometrium like adenoeareinoma (3 cases) , clear cell carcinoma (2 cases) and metastatic poorly differentiated adenoeareinoma of unknown origin ( 1 case) . All patients received relatively thorough surgical resection combined with multiple courses of adjuvant chemotherapy. Results: One of the patient with EPSPC survives for 90 months up to October 2004, one case serous adenocarcinoma survives for 92 months up to December 2004 , and the other one endometrium like adenocarcinoma survives for 76 months up to now. The average survival time of 8 patients who died of their diseases (EPSPC) was 12. 8 months, being longer than that reported in the literature. Conclusion: Following accurate diagnosis of normal - sized ovary carcinoma syndrome, radical tumor resection is the firstchoice of treatment. . For residual tumor, postoperative chemotherapy is essential to obtain better prognosis.
出处
《中国妇幼保健》
CAS
北大核心
2005年第23期3060-3063,共4页
Maternal and Child Health Care of China