摘要
In the present paper,FT-mid-IR fiber optics spectroscopy was used to determine the thyroid tumor.A modified WQF-500 FTIR spectrometer with MCT detector and mid-IR fiber optics ATR accessory was used in this work.Percutaneous examination of the skin overlying the thyroid tumor was performed on five patients,in vivo detection and in vitro measurement of six patients in operation room was also carried out.The experimental data indicate that malignant and benign thyroid tumor could be distinguished from the spectra of percutaneous examination,the in vivo measurement and freshly resected thyroid tissues.The relative intensity and peak position of the IR bands in the region of 1 700-1 500 cm-1(amide Ⅰ and amide Ⅱ),1 480-1 400 cm-1,and 1 320-1 200 cm-1 are reliable spectral marker or indexes for tumor detection.These results demonstrate that FT-mid-IR fiber optics spectroscopy exhibits prospect to develop a novel non-invasive method for thyroid tumor detection.
In the present paper, FF-mid-IR fiber optics spectroscopy was used to determine the thyroid tumor. A modified WQF-500 FTIR spectrometer with MCT detector and mid-IR fiber optics ATR accessory was used in this work. Percutaneous examination of the skin overlying the thyroid tumor was performed on five patients, in vivo detection and in vitro measurement of six patients in operation room was also carried out. The experimental data indicate that malignant and benign thyroid tumor could be distinguished from the spectra of percutaneous examination, the in vivo measurement and freshly resected thyroid tissues. The relative intensity and peak position of the IR bands in the region of 1 700--1 500 cm^-1 ( amide Ⅰ and amide Ⅱ ) , 1 480- 1 400cm^-1, and 1 320-1 200cm^-1 are reliable spectral marker or indexes for tumor detection. These results demonstrate that FF-mid-IR fiber optics spectroscopy exhibits prospect to develop a novel non-invasive method for thyroid tumor detection.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2005年第12期2227-2229,共3页
Chemical Journal of Chinese Universities
基金
国家重点基础研究发展规划项目(批准号:2002CCA01900)
国家自然科学基金(批准号:30371604
50203001)
教育部博士学科点基金资助