南中国海星骨海绵Stelletta sp.中的三萜化合物

Triterpenoids from the Sponge Stelletta sp.Collected from the South China Sea

Three isomalabaricane and malabaricane triterpenoids（1-3） were isolated from the sponge Stelletta sp.collected from Weizhou Island,Guangxi Province.The structures of compounds 1-3 were identified mainly by spectroscopic methods and X-ray diffraction analysis.All 1H NMR and 13C NMR signals of compound 1 were assigned for the first time on the basis of HMQC,<sup>1H-<sup>1H COSY and HMBC experiment.Antitumor assay exhibits that compounds 1,2 and 3 have a significant antitumor activity against P388 tumor cell lines with ED50 values 0.01,0.5,1.0 μg/mL,respectively.

Three isomalabaricane and malabaricane triterpenoids （1-3） were isolated from the sponge Stelletta sp. collected from Weizhou Island, Guangxi Province. The structures of compounds 1-3 were identified mainly by spectroscopic methods and X-ray diffraction analysis. All I H NMR and ^13C NMR signals of compound 1 were assigned for the first time on the basis of HMQC, ^1H-^1H COSY and HMBC experiment. Antitumor assay exhibits that compounds 1, 2 and 3 have a significant antitumor activity against P388 tumor cell lines with EDso values 0.01, 0.5, 1.0μg/mL, respectively.