托烷司琼与格拉司琼预防妇科腹腔镜术后恶心呕吐的比较

Comparison between tropisetron and granisetron in preventing postoperative nausea and vomiting for gynecologic laparoscopic surgery

目的:比较托烷司琼与格拉司琼预防妇科腹腔镜术后恶心呕吐的临床疗效.方法:选择90例ASAⅠ～Ⅱ级行妇科腹腔镜手术的患者随机均分为三组,在手术结束时分别静脉注射托烷司琼5 mg(T组,n=30)、格拉司琼3 mg(G组,n=30)、生理盐水5 mL(对照组,NS组,n=30).结果:在术后8 h内和9～24 h恶心呕吐发生率T组(20.0%,10.0%)和G组(20.0%,33.3%)明显低于NS组(63.3%,60.0%)(P＜0.05),T组在术后8 h内恶心呕吐发生率与G组比较无显著性差异(P＞0.05),但在术后9～24 h内恶心呕吐发生率明显低于G组(10.0% vs 33.3%)(P＜0.05).结论:托烷司琼与格拉司琼均可有效预防妇科腹腔镜术后恶心呕吐发生率,但托烷司琼的远期效果优于格拉司琼.

Objective To compare the clinical effect of tropisetron and granisetron in preventing postoperative nausea and vomiting for gynecologic laparoscopic surgery. Methods Ninity patients, ASA class Ⅰ～Ⅱ ,undergoing gynecologic laparoscopic surgery,were randomly divided into 3 groups, receiving an intravenous bolus of tropisetron 5 mg （group T,n=30）,granisetron 3 mg （group G,n= 30 ）,or 0. 9% NS 5 mL （group placebo,group NS,n = 30） respectively at Results The incidences of postoperative nausea and vomiting in group T （20.0 （20.0%,33.3%） were significantly lower than those in group NS （63 3% the end of the surgery. %,10.0%） and group G ,60. 0%） （P〈0. 05） in postoperative 8 hours and 9-24 hours. The incidence of postoperative nausea and vomiting in group T was similar to that in group G in postoperative 8 hours （P〈0.05） ,but significantly lower than that in group G in postoperative 9-24 hours （10.0% vs 33.3%） （P〈0.05）. Conclusion Tropisetron and granisetron can prevent postoperative nausea and vomiting of gynecologic laparoscopic surgery effectively,but the long-dated effects of tropisetron was better than that of granisetron.