急性白血病患者血浆VEGF、组织因子的测定及其临床意义

Clinical significance of plasma VEGF and TF concentration in acute leukemia

目的:探讨急性白血病患者血浆血管内皮细胞生长因子、组织因子含量变化与临床病情的关系。方法:用双抗体夹心酶联免疫吸附法检测32例急性白血病患者血浆血管内皮细胞生长因子、组织因子含量。结果:急性白血病初治患者血浆血管内皮细胞生长因子、组织因子含量明显高于对照组,也明显高于缓解组(P<0.005或0.001),且急性白血病患者血浆升高组织因子与血管内皮细胞生长因子增加呈正相关(r=0.51,P<0.005);未缓解组患者血浆血管内皮细胞生长因子、组织因子与初治组比较差异无显著性意义(P>0.05)。结论:急性白血病患者血浆组织因子、血管内皮细胞生长因子含量与临床病情变化密切相关,可作为了解病情、观察疗效、判断预后的指标之一。

Objective To investigate the relationship between the concentration of plasma VEGF, TF and clinical condition in acute leukemia. Methods The concentration of plasma VEGF and TF in 32 patients with acute leukemia was detected by ELISA. Results The plasma VEGF and concentration in the acute leukemia group was significantly higher than those in control and remission group（P〈0.05 or 0.01）. There was no significant difference between the untreated group and no-remission group （ P 〉0.05）. There was linear correlation between the plasma TF and VEGF concentration （r=0.51, P 0. 05）. Conclusion The concentration of plasma VEGF and TF is significantly associated with clinical condition, which can be the indicators for learning clinical features and predicting prognosis of acute leukemia patients.