摘要
分析了52例急性髓系白血病(AML)患者的血浆总胆固醇(T-chol)水平,发现初发患者的血浆T-chol水平明显低于正常对照组,并与外周血白细胞数和白血病细胞所占比例呈负相关,单核细胞型AML患者血浆T-chol水平最低,经治疗完全缓解后血浆T-chol浓度明显上升。表明AML的低胆固醇血症与肿瘤细胞负荷和肿瘤细胞亚型有关。
Plasma total cholesterol concentrations were analysed in 52 acute myeloye-nous leukemia (AML) patients. The initial levels of plasma total cholesterol in AML were markedly lower than those in the normal control group ,and showed negative correlation with the counts of white blood cells and the ratio of leukemic cells in the peripheral blood. The lowest cholesterol levels were observed in AML patients with monocytic subtype. Complete remission was associated with a significant incresse in cholesterol levels in AML patients. The results support the idea that hypocholes terolemia in AML is related to the tumorous mass and the subtype of leukemic cells.
