中草药神经保护作用机制的研究现状

Present research on neuroprotective effects of Chinese medicinal herb

目的:探讨中草药部分药学成分对神经元细胞病理损伤的恢复作用。资料来源:应用计算机检索PubMed 1999-01／2001-12与中药的神经保护作用相关的文章,检索词为“herb,neural protection”,限定文章语言种类为英文。同时检索“万方数据库”1996-01／2003-12与中药的神经保护作用相关的文章,检索词为“中药疗法、神经保护药”,限定文章语言种类为中文。资料选择:对资料进行初筛,选取针对性强的文章。同一领域的文献则选择近期发表或权威杂志的文章。然后,对筛选出的文献查找全文。资料提炼:共收集到25篇与中药的神经保护作用相关的文章,其中8篇来源于近期发表或权威的杂志,符合纳入标准。资料综合:多项观察结果显示,部分中草药的药学成分对神经细胞的损伤有治疗及保护作用。这种作用表现在以下途径中:对抗钙离子的细胞内流、降低氧自由基水平、对抗细胞凋亡、抑制兴奋性氨基酸的不良作用及拟雌激素样作用。结论:中草药的部分药学成分黄芩甙、银杏内酯、芹菜素、三七总皂甙、川芎嗪、丹参酮、丹参素、人参皂甙等对神经细胞的损伤有治疗及保护作用。

OBJECTIVE： To observe the rehabilitative effect of part of pharmacocomponent of Chinese medicinal herbs on pathologically harmed neuronal cells. DATA SOURCES： We searched the PubMed database for relative data on protective effect of herb on harmed neural cells published from January 1999 to December 2001, with the key words “herb, neural protection” in English. Meanwhile, we also searched Wanfang Database for neural protective effects of traditional Chinese medicine published from January 1996 to December 2003 with the same key words in Chinese. STUDY SELECTION： All the data were selected primarily, and those relative data with great relevance were selected. Articles in the same field, literatures that published lately or published in authoritative journals were included. Full-texts of the included articles were searched. DATA EXTRAGTION： Totally 25 articles on ..eural protective effects of herbs, in which 8 articles were published lately or from authoritative journals, which accorded with the inclusion criteria. DATA SYNTHESIS： Many studies revealed that pharmacological elements of herbs had protectively treatment effects on harmed neural cells. The effect relied on the following mechanisms： resisting intracellular elevation of calcium, reducing oxygenic free radical, anti-apoptosis of cells, inhibiting scathe of exciting amino acid, having similar function of female hormone. CONCLUSION： Parts of pharmacological elements of herbs： haicalin, maidenhair lactone, celery seed, panax notoginseng saponins, ligustrazine, dan-shen root keton, danshensu and ginseng saponin, etc. have protectively treatment effects on injury＇of neural cells.